-change colors (the obvious one *g*) -change fonts! (this will hopefully be easier in the future as I quietly campaign for more webfont support). But at the very least, you can mix up serif and sans-serif fonts to decent effect in header vs body text -add images! most of the layouts support a bunch of different background imageds, and places like photobucket and imgur will let you link stuff there. There's a list of background patterns on dreamscapes here - even just using one page background image can change things up a bit (for ex, onifukuchou, which is Marginless with a background image and some custom colors. -Change modules around! Disable ones you don't use, change the order of ones you do - particularly if you like having your main content take up most of the space, and want to use one of the one-column modes
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-change fonts! (this will hopefully be easier in the future as I quietly campaign for more webfont support). But at the very least, you can mix up serif and sans-serif fonts to decent effect in header vs body text
-add images! most of the layouts support a bunch of different background imageds, and places like photobucket and imgur will let you link stuff there. There's a list of background patterns on dreamscapes here - even just using one page background image can change things up a bit (for ex,
-Change modules around! Disable ones you don't use, change the order of ones you do - particularly if you like having your main content take up most of the space, and want to use one of the one-column modes